The Washington Post has a map of the regions of North America. It refers to them as "nations" but it seems to me the divisions are less strong than they were when I was quite young. Also, I expect the borders of these regions have drifted somewhat over the decades and will continue to drift over time.
Like many people in Michigan in the 1940s, my parents moved there from Greater Appalchia. The jobs were there both in the auto industry and during the war and it's build-up, and there were loads of ancillary industries that sprang up as well.
So I was raised in what this map calls "Yankeedom" but I had close familial ties to Greater Appalachia. I also had many friends whose parents had migrated from Greater Appalachia or the Deep South.
I received the bulk of my education from grade school up to grad school in Yankeedom. But I have lived the large majority of my life in The Midlands, with brief sojourns into The Far West.